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Charles V (1500-1558) ruled the Holy Roman Empire from 1519 to 1556 and was also ruler of Castile/Aragon/Spain, Valois, Burgundy, Austria and colonies in the America's and Philippines. He was the nephew of Catherine of Aragon, wife of English king Henry VIII. In 1527 during one of the four wars with France, Charles imprisoned Pope Clement VII (the Pope who crowned him Emperor), making it unlikely Henry's marriage to Catherine would ever be annulled. Later, Charles' son Philip married Henry's daughter, Mary.